The Hoskins lab in the Department of Biochemistry at the University of Wisconsin-Madison is currently seeking to hire one outstanding post-doctoral research scientist in the fields of RNA biochemistry and biophysics. This position is funded by a R00 award from the NIH and interested scientists looking for a position starting in the Fall of 2012 or later are encouraged to apply.
Research in the lab focuses on using novel chemical and physical methods to study the mechanisms of pre-mRNA splicing. Specifically, we are interested in how snRNPs associate with cognate pre-mRNA sequences and how these interactions can be modulated to enforce splicing fidelity and/or bring about alternative splicing.
To study these interactions we use cutting edge microscopy techniques in vitro and in vivo. One such method is CoSMoS (Colocalization Single Molecule Spectroscopy). This method allows us to probe complicated assembly reactions in complex environments at the single molecule level. In addition to CoSMoS, the Hoskins lab is developing novel fluorescence and single molecule fluorescence methods for use in vitro and in vivo. For further details please see:
1. Hoskins AA, Friedman LJ, Gallagher SS, Crawford DJ, Anderson EG, Wombacher R, Ramirez N, Cornish VW, Gelles J, Moore MJ: Ordered and dynamic assembly of single spliceosomes. Science 2011, 331:1289–1295.
2. Hoskins AA, Gelles J, Moore MJ: New insights into the spliceosome by single molecule fluorescence microscopy. Current opinion in chemical biology 2011, 15:864–870.
Enthusiastic and highly-motivated candidates should have a strong background either in RNA biochemistry or biophysics. Experience with yeast genetics or single molecule measurements is a plus, although not required. Candidates will be expected to contribute to a driven research team in a thriving academic environment that spans a wide range of interests.
Applicants should send their CV, a 1 page statement of research interests and experience, and the names/contact information for 3 references to ahoskins@wisc.edu via email.
We are an Equal Opportunity Employer and applications from individuals with backgrounds underrepresented in the sciences are encouraged.