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Position available in Dept. of Genetics and Developmental Biology of the University of Connecticut Health Center , Farmington, United States
Position posted on Monday, June 08, 2009

The University of Connecticut Health Center (UCHC) Translational Genomics Core (TGC) is an active provider of microarray services to University and external researchers: processing over 1,000 samples per year to perform gene-expression, genotyping, and other genomic analyses using the Illumina, Affymetrix, Agilent, and Nimblegen platforms. In addition, the TGC has an Illumina Genome Analyzer and provides next-generation sequencing technology to our users. We seek an exceptional candidate to participate in and direct the daily activities of this Core. Regular duties include providing assistance with the planning of experiments, participating in core-laboratory strategic planning, educational outreach, overseeing laboratory technicians, microarray and sequencing sample processing, and quality control.
Qualified candidates will have a Ph.D. in nucleic acid chemistry, genetics/genomics, bioinformatics or a related field and/or at least two years of microarray sample-processing experience. Special attention will be given to candidates with management experience and/or a record of achievement in a service-oriented organization. The successful candidate will be appointed at an academic rank commensurate with experience. Interested candidates should forward their resumes and three letters of reference to:
Translational Genomics Core Search Depatment of Genetics and Developmental Biology niversity of Connecticut Health Center 263 Farington Avenue Farmington, CT 06030-3301

Contact :
Dr Brenton R. Graveley
Tel : 860-679-2090
Email : graveley[at]neuron.uchc.edu


Position available in Dept of Biochemistry of the Purdue University , West Lafayette, United States
Position posted on Monday, June 08, 2009

A postdoctoral position (3-5 years) is currently available after August 3, 2009 to study the role of DEAD-box proteins in nuclear mRNA export. Gene expression in eukaryotes requires the active transport of mRNAs transcribed in the nucleus to the site of translation in the cytoplasm. Although the factors involved in this process are known, the precise mechanism for mRNA export has not been defined. Recently, DEAD-box proteins have been shown to promote export through alteration of the mRNA:protein (mRNP) complex composition (Tran et al. Mol. Cell 2007), suggesting that this remodeling drives the export process.

Our goal is to understand how DExD-box proteins, and mRNP remodeling, promote movement of a message from the nucleus to the cytoplasm. Our research combines genetics, biochemistry and cell biology using the budding yeast Saccharomyces cerevisiae as a model system.

Interested individuals should e-mail a cover letter describing your current research and future research interests along with an attached CV to the address listed below. Previous experience in protein purification, fluorescent microscopy, RNA: protein biochemistry and/or yeast genetics is preferred.

Contact :
Dr Elizabeth Tran
Tel : 615-498-9065
Email : elizabeth-j-tran[at]purdue.edu


Position available in Dept of Chemistry of the University of Michigan , Ann Arbor, United States
Position posted on Monday, June 08, 2009

Immediately available for at least a year is a postdoctoral research position in single molecule fluorescence microscopy and NMR spectroscopy of RNA in the group of Professor Nils G. Walter at the University of Michigan, Ann Arbor, USA. The project involves highly interdisciplinary, National Institutes of Health funded work targeted at real-time fluorescence imaging and advanced NMR spectrocopy of the hepatitis delta virus, or HDV ribozyme. Highly motivated and enthusiastic candidates are sought with experience in RNA biochemistry, fluorescence and/or other spectroscopies, and the enthusiasm to learn state-of-the-art biophysical techniques. Those with the appropriate background should review the group’s web page at: http://www.umich.edu/~rnapeopl and send their Curriculum Vitae and the names and addresses of three references to Dr. Nils G. Walter, Associate Professor of Chemistry, via email: nwalter[at]umich.edu. Please note that the University of Michigan is a top research university situated in one of the most livable cities in the US.

Contact :
Dr Nils G. Walter
Tel : (734) 615-2060
Fax : (734) 647-4865
Email : nwalter[at]umich.edu


Position available in Center for Childhood Cancer of the The Research Institute at Nationwide Children's Hospital and The Ohio State University , Columbus, United States
Position posted on Tuesday, May 26, 2009

A postdoctoral position is available immediately for a scientist with experience in molecular and/or cancer biology. The Chandler lab is investigating the link between alternative splicing, the p53 pathway, and pediatric soft tissue sarcomas of the muscle called rhabdomyosarcomas. The appointee will investigate molecular mechanisms involved in the induction of alternative splicing of the p53 pathway. This will include investigating the links between DNA damage and RNA processing as well as p53 activity. A major focus of the laboratory is on p53 modulators MDM2 and MDMX. Cell culture, in vitro splicing and mouse models serve as systems in which to study the mechanism for alternative splicing as well as the biological endpoints of the pathways. The laboratory's approaches include integration of cell biology, molecular biology, genetics, and biochemistry.

Expertise in molecular biology, genetics, and/or biochemistry is preferred. Experience in RNA processing is desirable. The successful candidate will confer regularly with the principal investigator but must incorporate self-directed research, excellent technical, presentation, and communication skills as essential parts of the job. Must have Ph.D. degree in relevant field of science from an accredited college. Coursework in biochemistry, anatomy, physiology, statistics, relevant research methods and radiation desirable. Animal experience (mouse/rat) a plus.

Interested applicants should send a cover letter summarizing research interests and career goals, curriculum vitae, brief description of research experience, and contact information for three references to Dawn Chandler by e-mail to dawn.chandler[at]nationwidechildrens.org.

For more information, please visit: http://chandlerlab.nchresearch.org

Contact :
Dr Dawn S. Chandler
Tel : 614-722-5598
Fax : 614-722-5895
Email : dawn.chandler[at]nationwidechildrens.org


Position available in Dept of Cell Biology of the Cleveland Clinic , Cleveland, United States
Position posted on Tuesday, May 26, 2009

We would like to recruit a Post-Doctoral Fellow or Research Associate to join our research program on RNA elements and RNA–protein interactions (and uninteractions) in translational control of inflammatory gene expression (see Jia, J. et al., Mol. Cell 29: 679-690, 2008; Ray, P.S. et al., Nature 457: 915-919, 2009). Studies range from the molecular level, through mammalian cells, to mice and humans. Qualifications include a Ph.D. or M.D., and demonstrated experience and creativity in studies of RNA biology/biochemistry as evidenced by excellent publications and strong recommendation letters. The position is open immediately. The Lerner Research Institute of the Cleveland Clinic offers a stimulating and collaborative scientific environment with competitive benefits.

Contact :
Dr Paul L. Fox
Tel : 216-444-8053
Email : foxp[at]ccf.org


Position available in Dept. of Research of the New England Biolabs Inc. , Ipswich, United States
Position posted on Monday, May 04, 2009

The RNA Biology Division invites applications for the position of Postdoctoral Fellow to be filled immediately, and for a period of two years. Projects will be a part of a discovery-based basic research program into gene regulation mediated by small RNA, RNA interference, and related pathways in mammals (see Robb G. B. and Rana T. M. (2007) Mol. Cell 25;26(4):523-37, and Robb G. B. et al. (2005) Nat Struct Mol Biol. 2005 Feb;12(2):133-7.). Research will be undertaken in a highly collaborative and
academic environment where publication of results is expected.

Primary responsibilities of the candidate will be:
* to carry out original scientific research
* to be a creative, independent and productive scientist with a strong background in cell and molecular biology
* to interact and collaborate with the other members of the RNA biology and other research divisions to further program and division goals.

This position requires technical expertise in:
* RNA manipulation and analysis
* Mammalian cell culture
* Standard molecular biology techniques

A recent Ph.D. and a demonstrated record of research accomplishments are also required, and will include publication of original scientific work in high-quality journals, and scientific communication in both formal and informal settings. This position offers exciting opportunities for broad research training, academic collaboration, publications in peer-reviewed journals and participation in national and international conferences.

Please forward your C.V. and statement of interest to: resumes[at]neb.com Attn: Job Code 1042BR

New England Biolabs, Inc. is an equal opportunity employer. M/F/D/V

Contact :
Dr Brett G Robb
Tel : 1-800-632-5227
Email : robb[at]neb.com


Position available in Dept of Cell Biology of the Cleveland Clinic Foundation , Cleveland, United States
Position posted on Sunday, April 19, 2009

A postdoctoral position is available for a scientist with training in molecular and/or developmental biology. Research will use a combination of molecular and embryological approaches to investigate the role of pre-mRNA alternative splicing regulatory programs in vertebrate heart development. Good English language skills and a Ph.D. or M.D. in a relevant discipline are required. Recent graduates and those with US citizenship or permanent residence status are encouraged to apply. The position is available immediately and will remain open until filled.
The Cleveland Clinic offers an excellent work environment with competitive benefits. Initial appointment is for one year, with the expectation of annual renewal for two to five years contingent upon review. Interested applicants should send a cover letter summarizing research interests and career goals, curriculum vitae, brief description of research experience, and contact information for three references to Dr. Andrea N. Ladd via email to: ladda[at]ccf.org.
For more information, please visit: http://www.lerner.ccf.org/cellbio/ladd/

Contact :
Dr Andrea N. Ladd
Tel : 216-445-3870
Fax : 216-444-9404
Email : ladda[at]ccf.org


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