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Position available in Department of Biochemistry and Molecular Biology of the University of Georgia , Athens, United States
Position posted on Monday, February 11, 2008
The Department of Biochemistry and Molecular Biology invites applications from outstanding candidates for a tenure track faculty position at the Assistant or Associate Professor level. This search is open to candidates wishing to pursue interests in any specialty within biochemistry and molecular biology. The Department has established strengths in structural biology, computational biology and bioinformatics, the biochemistry and molecular biology of RNA, signal transduction, extremophile and metalloenzyme biochemistry, as well as plant and animal glycobiology (further information is available at http://www.bmb.uga.edu/home/). Candidates with research interests that expand or complement existing departmental strengths are particularly encouraged, but all outstanding applicants will be carefully considered. Applicants must have a Ph.D. degree (or equivalent), postdoctoral experience, a solid publication record and a well-developed research plan. The successful candidate will be expected to establish a strong extramurally funded research program and contribute to teaching in the Department.
To apply, submit a cover letter, CV, and a description of research and teaching interests to rita@bmb.uga.edu electronically (indicate biochemistry open search in the subject line). Applicants should arrange to have at least three letters of reference sent to: Open Search Committee Chair, c/o Ms. Rita Hutchins, Department of Biochemistry and Molecular Biology, University of Georgia, Life Sciences Building, 120 Green Street, Athens, GA 30602-7229. Electronic letters of recommendation on letterhead are acceptable. Complete applications received by February 14, 2008 are assured of full consideration.
The Franklin College of Arts and Sciences, its many units, and the University of Georgia are committed to increasing the diversity of its faculty and students, and sustaining a work and learning environment that is inclusive. The University is an EEO/AA institution.
Contact :
Dr Michael and Becky Terns
Tel : 706-542-1703
Fax :
Email : mterns[at]bmb.uga.edu
Position available in Institute for Comprehensive Medical Science, Division of Gene Expression Mechanism of the Fujita Health University , Toyoake, Japan
Position posted on Friday, February 01, 2008
The Institute for Comprehensive Medical Science is an affiliated research institute of the
Fujita Health University that was founded by the late Dr. Keisuke Fujita. Under the
leadership of new director, Dr. Yoshikazu Kurosawa, this institute is going to be
renovated with young Professors (from thirties to forties) including two new Professors
(Drs. Akila Mayeda and Tsuyoshi Miyakawa) who have been recently appointed. The
Principle Investigator (Professor) organizes each research division (total 6 laboratories)
with 4 laboratory staffs (Associate Professor and/or Assistant Professors) and they are
fully supported by the University as junior faculty members. There is no teaching duties,
including lecture, course, practice, and guidance of students. A research-oriented
program with attractive resources in the institute will be available. This AD is searching
for the laboratory staffs of Dr. A. Mayeda, who has been appointed as a new Professor of
the Division of Gene Expression Mechanism.
LABORATORY
The Division of Gene Expression Mechanism is studying basic molecular mechanism of
pre-mRNA splicing of human genes using biochemical and molecular biological
approaches. See the URL (see below) for the detailed research activities sin this division.
POSTS OPENED
2 posts for Assistant Professor (more likely as Staff Associate in the US; it is not fully
dependent post) in the Division of Gene Expression Mechanism. The scientist belongs to
the Mayeda's laboratory, but his/her competitive salary and fringe benefits will be fully
supported by the Fujita Health University.
ELIGIBILITY
Applicants should hold a Ph.D. and/or M.D. degree with a record of excellent
productivity in an area of molecular biology, biochemistry, or bioinformatics that
complements the existing research of the laboratory. Postdoctoral research training in the
research field of RNA is desirable. International postdoctoral fellows are welcome
(applicants must be proficient in English but Japanese is not essential). The candidate
should possess the ability to work collaboratively with other scientists in the lab.
APPLICATIONS
Please send the application file including; (1) Current CV (including publication list), (2)
Description of previous research accomplishments (within 1 page), (3) Statement of
research interest (within 1 page), (4) Up to 5 reprints of original papers, and provide (5)
the names and contact information of four references, to the following e-mail address as
attachments (either PDF or MS Word file). If e-mail is not available, regular airmail or
express mail to the following address is also acceptable. The successful applicants will
be invited for the seminar and interview (but cost of travel won’t be supported by the
University). The results of the search will be informed via e-mail.
DEAD LINE
April 21, 2008; or until the post is filled.
STARTING DATE
July 1, 2008 as the earliest (negotiable)
Contact :
Dr Akila Mayeda
Tel : 93-9377
Fax : 92-5382
Email : mayeda[at]fujita-hu.ac.jp
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Position available in Dept of Cell Activation and Gene Expression of the IBMC , Porto, Portugal
Position posted on Saturday, March 15, 2008
We are looking for highly motivated Post-doc, to work in my group at the Institute for Molecular and Cell Biology (IBMC), with experience in at least one of the following: transfection and expression in eukaryote systems; RNA interference; flow cytometry; biochemistry of signal transduction/cell activation; RNA techniques. Experience in knockout or transgenic animals is advantageous as well.
The candidate should possess a PhD in the fields of Biomedicine, Biology, Biochemistry, Molecular Biology or related areas. The proposals should include a letter of motivation, CV, 2 reference letters, and copies of the major publications.
The post-doc fellowship has the duration of 36 months to start as soon as possible. Net monthly allowance is €1,495.00
Description fo the project:
"Alternative spliced isoforms of CD6: on the cross-roads of T cell activation and the regulation of lymphocyte development"
We have recently described a novel alternatively spliced isoform of CD6 (Castro, M.A.A. et al., (2007) “Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse”, J. Immunol., 178: 4351-4361), a surface glycoprotein expressed at the surface of T lymphocytes and a sub-population of B cells. The novel isoform of CD6 is alluring since it lacks the ligand-binding domain 3, which is coded by exon 6, so it is unable to interact with the ligand, CD166, present on antigen presenting cells. The remarkable functional consequence is that none of these molecules target to the immunological synapse upon antigen presentation and T cell:APC conjugation. In the current proposal we aim at characterizing the molecular mechanisms behind this type of gene regulation, and the biological and physiological consequences of the choice between different isoforms. The subject of the study will be the CD6 gene and protein products, focusing on the regulation of expression of the ligand-binding domain.
We will investigate the regulation of alternative splicing of alternatively spliced exon in cell cultures. Using monoclonal specific antibodies we will characterize thymocyte sub-populations for the expression or absence of the alternatively spliced domain, by FACS and addressing the expression of development-markers CD4, CD8, CD3, CD34 and CD1a. Mice will be generated with the forced expression, or with the forced absence of the alternatively spliced exon, and investigate the roles of domain 3 may have in T lymphocyte development and in T cell activation of mature cells.
Contact :
Dr Alexandra Moreira Carmo
Tel :
Fax :
Email : amcarmo[at]ibmc.up.pt
Position available in School of Biological Sciences of the University of Missouri - Kansas City , Kansas City, United States
Position posted on Tuesday, February 26, 2008
Multiple positions are avialable to study posttranscriptional regulation of gene expression in plants, using global transcriptional profiling, affinity tagging / mass spectrometry and systems biology tools (e.g. see our recent paper in Cell 131:1340-1353 (2007)), or/and new connections between gene regulation and 3D organization of cell nucleus in yeast (see our recent papers in RNA 14:66-77 (2008) and EMBO J 25:4253-4256 (2006)). The lab is equipped with Affymetrix and deconvolution microscopy workstations and have on-site access to MALDI, ESI LC-MS/MS and high-end Linux cluster. Postdoctoral fellowships eligibility helpful but not essential (while documented record of excellence is). Funding is available through 2011. Kansas City is a major cosmopolitan center of 2.5M-plus people and offers dynamic cultural environment, vibrant music scene, fabulous restaurants and has been profiled as one of the best places to live in US (see www.cnn.com/2006/TRAVEL/DESTINATIONS/06/08/kansas.city/index.html)
Contact :
Dr Dmitry Belostotsky
Tel : 816 235 5358
Fax :
Email : belostotskyd[at]umkc.edu
Position available in Institute of Cell Biology of the University of Bern , Bern, Switzerland
Position posted on Tuesday, February 26, 2008
Two post-doctoral research positions are available in the laboratory of Dr. Oliver Mühlemann to investigate mechanisms of mRNA surveillance and their role in gene regulation.
“Nonsense-mediated mRNA decay” (NMD) represents a surveillance mechanism that recognizes and degrades mRNAs of which the protein coding potential is truncated by the presence of a premature termination codon (PTC). One main goal of our research is to understand at the molecular level how PTCs are recognized and distinguished from correct termination codons, and how this recognition of nonsense mRNAs subsequently triggers their rapid degradation. Our latest results indicate that the physical distance between the terminating ribosome and the poly(A) tail is a crucial determinant for PTC definition (Buhler et al., NSMB 13:462) . These findings suggest a novel post-transcriptional mechanism for gene regulation, a hypothesis that we want to scrutinize in the coming years.
In addition to triggering NMD, we discovered that PTCs in certain immunoglobulin genes also lead to transcriptional silencing of the corresponding gene (Buhler et al., Mol Cell 18:307). We now investigate the biological relevance of this novel quality control mechanism termed “nonsense-mediated transcriptional gene silencing” (NMTGS) and want to identify the involved molecules and their interactions.
The planned research employs state-of-the-art biochemistry, genetic engineering and modern cell & molecular biology techniques.
Suitable candidates hold a PhD in the field of molecular and cellular biology or biochemistry and have practical experience with RNA analysis and cell culture work. Know-how in bioinformatics would be an additional asset.
Applications (including CV, publication list and the coordinates of three references) should be sent electronically to oliver.muehlemann[at]izb.unibe.ch
Contact :
Dr Oliver Muhlemann
Tel :
Fax :
Email : oliver.muehlemann[at]izb.unibe.ch
Position available in Dept of Directors' Research of the EMBL/MMPU , Heidelberg, Germany
Position posted on Monday, February 11, 2008
We are an international, dynamic RNA group at the interface of basic and medical research. Our specific interest is in NMD and 3’end processing mechanisms and their associated diseases. We are currently searching for 2 active post-docs, who will be financed by available grants and by funds (2-3 year projects) provided by the Heidelberg University research prize.
We offer exciting projects that focus on the biochemical and the functional characterization of the exon junction complex and on the chemical biology of RNA processing. You will be a member of the Molecular Medicine Partnership Unit, a joint venture of the Medical Faculty of Heidelberg University and of the European Molecular Biology Laboratory (EMBL).
You will have a strong background in RNA research and will have published as first author in international scientific journals. You will want to and be able to work independently within a highly interactive and motivated group of colleagues.
Interested? The positions are open immediately. Please visit our website (www.embl.org/research/partners/mmpu.html or www.klinikum.uni-heidelberg.de/RNA-processing-in-pediatric-blood-diseases.101686.0.html) and send your full application including names and e-mail addresses of two scientists who are willing to provide a detailed reference to Brigitte.konda[at]med.uni-heidelberg.de.
Contact :
Dr Matthias Hentze
Tel : 49-6221-562303
Fax :
Email : Brigitte.konda[at]med.uni-heidelberg.de
Position available in Dept. of RNA Biology of the Max Planck Institute for Infection Biology , Berlin, Germany
Position posted on Monday, February 11, 2008
Mechanisms of small noncoding RNA regulation
Applications are invited for a postdoc position in the RNA Biology Group at the Max Planck Institute for Infection Biology. The aim of the research is to func-tionally characterize noncoding regulatory RNAs of Salmonella that regu-late multiple target RNAs. We are particularly interested in i) which proteins are involved in multiple target mRNAs, and ii) if intracellular localization of small RNAs and target mRNAs matters for regulation. This project will include national and international collaborations with other groups working on related issues. For further information about the RNA biology group and our pub-lished work visit http://www.mpiib-berlin.mpg.de/research/RNABiology.htm
Applicants should hold a PhD degree, and should have a strong background in biochemistry, molecular and/or cell biology. The successful candidate will re-ceive a postdoctoral fellowship or salary according to the guidelines of the Max Planck Society (dependent on qualification) for up to 3 years.
The institute is located in the heart of Berlin on the historical Charité medical campus. It is well-equipped and has excellent core facilities. Berlin is a met-ropolitan city that offers a high quality of life, affordable accommodation and a vibrant cultural scene. We welcome applications from suitably qualified people from all sections of the community regardless of race, religion, gender or disability.
Applicants are encouraged to informally contact the head of the group, Jörg Vogel (vogel[at]mpiib-berlin.mpg.de; +49-30-28460-265) for more information on the planned projects. Applications, including a CV and the names and ad-dresses of two academic referees, should be sent by regular mail or email to:
Max Planck Institute for Infection Biology
Personalabteilung - Postdoc Vogel
Chariteplatz 1
10117 Berlin, Germany
e-mail: job[at]mpiib-berlin.mpg.de
Closing date: March 15, 2008
Contact :
Dr Joerg Vogel
Tel : +49-30-28460-265
Email : vogel[at]mpiib-berlin.mpg.de
Position available in Dept. of RNA Biology of the Max Planck Institute for Infection Biology , Berlin, Germany
Position posted on Monday, February 11, 2008
The Role of microRNA in Infections
Applications are invited for a postdoc position in the RNA Biology Group at the Max Planck Institute for Infection Biology. The aim of the research is to identify and functionally characterize microRNAs and other eukaryotic noncoding RNAs that play a role in Salmonella and further bacterial infections. We are going to use high-throughput sequencing, LNA chips and other assays to identify microRNAs differentially regulated upon infection. The downstream analysis of microRNA targets and functions requires a sincere interest in cell signalling processes and RNA biochemistry. We are also interested in possible infection-induced RNA interference processes on the eukaryotic host side. For further information about the RNA biology group visit
http://www.mpiib-berlin.mpg.de/research/RNABiology.htm
Applicants should hold a PhD degree, and should have a strong background in biochemistry, molecular and/or cell biology. The successful candidate will receive a postdoctoral fellowship or salary according to the guidelines of the Max Planck Society (dependent on qualification) for up to 3 years.
The institute is located in the heart of Berlin on the historical Charité medical campus. It is well-equipped and has excellent core facilities. Berlin is a metropolitan city that offers a high quality of life, affordable accommodation and a vibrant cultural scene. We welcome applications from suitably qualified people from all sections of the community regardless of race, religion, gender or disability.
Applicants are encouraged to informally contact the head of the group, Jörg Vogel (vogel[at]mpiib-berlin.mpg.de; +49-30-28460-265) for more information on the planned projects. Applications, including a CV and the names and addresses of two academic referees, should be sent by regular mail or email to:
Max Planck Institute for Infection Biology
Personalabteilung - Postdoc Vogel
Chariteplatz 1
10117 Berlin, Germany
e-mail: job[at]mpiib-berlin.mpg.de
Closing date: March 15, 2008
Contact :
Dr Joerg Vogel
Tel : +49-30-28460-265
Email : vogel[at]mpiib-berlin.mpg.de
Position available in Dept of Pathology and Cell Biology of the Columbia University , New York, United States
Position posted on Friday, February 01, 2008
A Post-doctoral position is available in the laboratory of Dr. Livio Pellizzoni at Columbia University to study the biogenesis and function of ribonucleoprotein complexes as well as the role of RNA dysfunction in the pathophysiology of inherited human motor neuron diseases. The research projects will focus on the characterization of the molecular functions of the survival motor neuron (SMN) protein, the Spinal Muscular Atrophy (SMA) disease gene product, in motor neurons and skeletal muscle using both cellular and animal model systems.
The candidate must hold a Ph.D. in the biological sciences and have strong laboratory expertise in biochemistry, molecular and cellular biology. Prior experience working with RNA-protein complexes is desired. Ideal applicants must have strong written/oral communication skills, ability to work effectively in a team environment and a proven record of research accomplishments.
Candidates should submit electronically a cover letter with a description of scientific interests and career goals, detailed curriculum vitae, and contact information for three references. This position is available immediately. The initial appointment is for one year with the possibility of extension.
Contact :
Dr Livio Pellizzoni
Tel : 212 305-3046
Fax : 212 342 0276
Email : lp2284[at]columbia.edu
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