Keystone Symposia: mRNA Processing and Human Disease

Scientific Organizers:
James L. Manley, Columbia University, USA
Siddhartha Mukherjee, Columbia University Medical Center, USA
Gideon Dreyfuss, HHMI/University of Pennsylvania School of Medicine

Submit an abstract and register for this Keystone Symposia conference that will take place March 58, 2017 at Sagebrush Inn & Suites, Taos, New Mexico, USA.

It has been known for decades that defects in mRNA processing can cause, or contribute to, numerous human diseases. The earliest examples of this involved simply mutations in cis-acting signal sequences (e.g., for splicing and polyadenylation) of target genes, for example the human beta globin gene in beta-thalassemia. But the number of diseases linked to defects in mRNA processing has increased dramatically in the last five to ten years, reflecting in large part insights from deep-sequencing efforts. Indeed, other more interesting mechanisms beyond cis-mutations have emerged, including changes in the concentrations of RNA-binding regulatory proteins and other processing factors in, for example cancer, and mutations that affect the function of not only regulatory proteins but also components of the core splicing machinery, which is seen in various cancers as well as several neurodegenerative diseases. The proteins involved function in a variety of aspects of gene expression, including splicing and polyadenylation/ 3’ end formation of mRNA precursors. Although previous meetings have touched on these topics, this will be the first to focus exclusively on links between mRNA processing and human disease. The meeting will bring together two groups that only infrequently overlap: scientists/physicians whose primary interests center on disease but who have become interested in RNA processing as a result, and scientists who study basic mechanisms of RNA processing and gene expression that have proven to be relevant to disease.

Session Topics:

  • mRNA Splicing and Links to Disease
  • RNPs and Disease
  • MDS, Leukemia and Splicing
  • RNA-Based Therapeutic Approaches
  • Splicing and ALS
  • Further Links between RNA Processing and Disease

Deadlin­es:

  • Scholarship & Discounted Abstract: November 2, 2016
  • Late-Breaking Abstract: December 6, 2016
    (for plenary short talk or workshop presentation consideration)
  • Discounted Registration: January 10, 2017

(Through this date, you can still submit an abstract via our website for poster presentation and publication in our mobile app.)

For more information and to register, please visit the meeting website:
http://www.keystonesymposia.org/17C3

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